By Peter M. Haddad, Serdar Dursun, Bill Deakin
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Risk factors for neuroleptic malignant syndrome; a case control study. Arch Gen Psychiatry, 46, 914–18. Keck PE, Pope HG, and McElroy SL (1991). Declining frequency of neuroleptic malignant syndrome in a hospital population. Am J Psychiatry, 148, 880–2. Kellam AMP (1990). The (frequently) neuroleptic (potentially) malignant syndrome. Br J Psychiatry, 157, 169–73. Kohen D and Bristow M (1996). Neuroleptic malignant syndrome. Adv Psychiatr Treat, 2, 151–7. Kohen D and Bristow M (1999). Atypical antipsychotics and neuroleptic malignant syndrome.
Although there are well documented cases of NMS occurring in elderly patients, over 80 per cent of cases are under 40 years of age (Caroff 1980), a finding that has been attributed to the use of higher doses of psychotropics in younger age groups. Recently, increased awareness of NMS, better understanding of psychopharmacological issues, decreased use of antipsychotic polypharmacy and of high doses of antipsychotic drugs have all assisted in decreasing the incidence of NMS (Gelenberg et al. 1988; Keck et al.
1992). Tardive Dyskinesia: A Task Force Report of the American Psychiatric Association. The American Psychiatric Association: Washington, DC. Kane JM (1999). Tardive dyskinesia. ), pp. 31–5. Blackwell Science: Malden, MA. Kapur S, Zipursky R, Jones C, et al. (2000). Relationship between dopamine D(2) occupancy, clinical response, and side effects: a double-blind PET study of first-episode schizophrenia. Am J Psychiatry, 157, 514–20. Kennedy PF, Hershon HI, and McGuire RJ (1971). Extrapyramidal disorders after prolonged phenothiazine therapy, including a factor analytic study of clinical features.
Adverse syndromes and psychiatric drugs: a clinical guide by Peter M. Haddad, Serdar Dursun, Bill Deakin